Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2, 5-dimethoxy-4-(2-butyl) phenyl]-2-aminopropane and 1-[2, 5-dimethoxy-4-(2- …

RA Oberlender, PJ Kothari, DE Nichols…

Index: Oberlender, Robert A.; Kothari, Paresh J.; Nichols, David E.; Zabik, Joseph E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 788 - 792

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Citation Number: 10

Abstract

Two novel hallucinogen analogues related to l-(2, 5-dimethoxy-4-methylphenyl)-2- aminopropane (DOM, STP) were synthesized and evaluated in the two-lever drug discrimination paradigm by using 0.08 mg/kg of LSD as the training drug stimulus. The two compounds differ from each other only with respect to the point of branching in the 4-alkyl group. However, pharmacological evaluation revealed a clear difference in potency and ...

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