Rearrangement of 1-aminoimidazolidine-4, 5-triones to 5-oxo-4, 5-dihydro-1, 2, 4-triazole-3-carboxylic acid

YA Rozin, NA Belyaev, VA Bakulev, I Leban…

Index: Rozin, Yu. A.; Belyaev; Bakulev; Leban; Azev, Yu. A. Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 12 p. 1534 - 1535

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Abstract

We have found that refluxing an aqueous suspension of compound 1a in the presence of hydrochloric acid and steam distillation of the aldehyde evolved gave 5-oxo-1, 2, 4-triazole-3- carboxylic acid 2a in 70% yield. Acid 2a was also prepared by us from 6-amino-2, 3, 4, 5- tetrahydro-1, 2, 4-triazine-3, 5-dione (4) by the method reported in the literature [1].