Synthesis and biological activity of chloro-substituted 1.5-diketones and their cyclization products

VG Kharchenko, SN Chalaya, LK Kulikova…

Index: Kharchenko, V. G.; Chalaya, S. N.; Kulikova, L. K.; Litvinov, O. V. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 500 - 503 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 824 - 826

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Abstract

Structural features of these chloro-substituted 1, 5-diketones lla-c are shown specifically in their reactions with nucleophilic reagents [5]. Reaction of chlorodiketones lla-c with ammonium acetate in acetic acid led to nucleophilic attack of the reagent on the carbonyl group and cyclization with formation of the 3-chloropyridines IVa-c. Reaction of lla-c with ammonia also gave IVa-c as well as the 2-benzoylpyrroles Va-c produced as a result of ...