Syntheses of 5-substituted oxazole-4-carboxylic acid derivatives with inhibitory activity on blood platelet aggregation.

尾崎泰彦， 前田貞夫， 岩崎為雄， 松本和男…

Index: Ozaki; Maeda; Iwasaki; Matsumoto; Odawara; Sasaki; Morita Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4417 - 4424

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Citation Number: 18

Abstract

No. 12 4417 iChCHL Pharm. Bu“. 31t12|4417 —4424(1983) Syntheses of 5-Substituted Oxazole-4-carboxylic Acid Derivatives with Inhibitory Activity on Blood Platelet Aggregation YASUHIKO OZAKI,*'“ SADAO MAEDA.“ TAMEO IWASAKI,“ KAzuo MATSUMOTO ...

 Related Synthetic Route
methyl 5-(4-ethylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-98-8

methyl 5-(4-eth...

~%

5-(4-ethylphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-06-1

5-(4-ethylpheny...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~77%

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-09-4

5-(3,4,5-trimet...

α-(3,4,5-Trimethoxyphenyl)acyl amino acid methyl ester hydrochloride Structure

38061-25-5

α-(3,4,5-Trimet...

~%

2-cyclohexyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-23-2

2-cyclohexyl-5-...

Cyclohexanecarboxylicacid, 1,1'-anhydride Structure

22651-87-2

Cyclohexanecarb...

~%

2-cyclohexyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-23-2

2-cyclohexyl-5-...

methyl 2-(cyclohexanecarboxamido)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate Structure

89205-29-8

methyl 2-(cyclo...

~%

2-cyclohexyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-23-2

2-cyclohexyl-5-...

α-(3,4,5-Trimethoxyphenyl)acyl amino acid methyl ester hydrochloride Structure

38061-25-5

α-(3,4,5-Trimet...

~%

2-phenyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-24-3

2-phenyl-5-(3,4...

Benzoic anhydride Structure

93-97-0

Benzoic anhydride

~%

2-phenyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-24-3

2-phenyl-5-(3,4...

methyl 2-benzamido-3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate Structure

89205-30-1

methyl 2-benzam...

~%

2-phenyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-24-3

2-phenyl-5-(3,4...

methyl 5-(4-methylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-96-6

methyl 5-(4-met...

~%

5-(4-methylphenyl)-1,3-oxazole-4-carboxamide Structure

89205-10-7

5-(4-methylphen...

methyl 5-(2,4-dimethylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-97-7

methyl 5-(2,4-d...

~%

5-(2,4-dimethylphenyl)-1,3-oxazole-4-carboxamide Structure

89205-11-8

5-(2,4-dimethyl...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-09-4

5-(3,4,5-trimet...

~%

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carbonyl chloride Structure

89205-25-4

5-(3,4,5-trimet...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~%

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carbonyl chloride Structure

89205-25-4

5-(3,4,5-trimet...

methyl 5-(4-ethylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-98-8

methyl 5-(4-eth...

~%

5-(4-ethylphenyl)-1,3-oxazole-4-carboxamide Structure

89205-12-9

5-(4-ethylpheny...

methyl 5-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate Structure

89205-01-6

methyl 5-(4-met...

~%

5-(4-methoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-13-0

5-(4-methoxyphe...

methyl 5-(3,4-dimethoxyphenyl)-1,3-oxazole-4-carboxylate Structure

89205-02-7

methyl 5-(3,4-d...

~%

5-(3,4-dimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-14-1

5-(3,4-dimethox...

methyl 5-(4-methylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-96-6

methyl 5-(4-met...

~%

5-(4-Methylphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-04-9

5-(4-Methylphen...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~76%

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-15-2

5-(3,4,5-trimet...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-09-4

5-(3,4,5-trimet...

~%

N-methyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-16-3

N-methyl-5-(3,4...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~%

N-methyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-16-3

N-methyl-5-(3,4...

Methylamine hydrochloride Structure

593-51-1

Methylamine hyd...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carbonyl chloride Structure

89205-25-4

5-(3,4,5-trimet...

~%

N-methyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-16-3

N-methyl-5-(3,4...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carbonyl chloride Structure

89205-25-4

5-(3,4,5-trimet...

isopropylamine Structure

75-31-0

isopropylamine

~83%

N-propan-2-yl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-17-4

N-propan-2-yl-5...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-09-4

5-(3,4,5-trimet...

~%

N-propan-2-yl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-17-4

N-propan-2-yl-5...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~%

N-propan-2-yl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-17-4

N-propan-2-yl-5...

methyl 5-(2,4-dimethylphenyl)-1,3-oxazole-4-carboxylate Structure

89204-97-7

methyl 5-(2,4-d...

~%

5-(2,4-dimethylphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-05-0

5-(2,4-dimethyl...

Dimethylamine hydrochloride Structure

506-59-2

Dimethylamine h...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carbonyl chloride Structure

89205-25-4

5-(3,4,5-trimet...

~93%

N,N-dimethyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-18-5

N,N-dimethyl-5-...

methyl 5-(3,4-dimethoxyphenyl)-1,3-oxazole-4-carboxylate Structure

89205-02-7

methyl 5-(3,4-d...

~%

5-(2,4-DIMETHYOXYPHENYL)-1,3-OXAZOLE-4-CARBOXYLIC ACID Structure

89205-08-3

5-(2,4-DIMETHYO...

5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxylic acid Structure

89205-09-4

5-(3,4,5-trimet...

~%

N,N-dimethyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-18-5

N,N-dimethyl-5-...

4-methoxycarbonyl-5-(3,4,5-trimethoxyphenyl)-oxazole Structure

38061-20-0

4-methoxycarbon...

~%

N,N-dimethyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-18-5

N,N-dimethyl-5-...

Trimethylgalloyl chloride Structure

4521-61-3

Trimethylgalloy...

N-MORPHOLINO-2-ISOCYANO-ACETAMIDE Structure

67434-29-1

N-MORPHOLINO-2-...

~59%

morpholin-4-yl-[5-(3,4,5-trimethoxyphenyl)-1,3-oxazol-4-yl]methanone Structure

89205-19-6

morpholin-4-yl-...

α-(3,4,5-Trimethoxyphenyl)acyl amino acid methyl ester hydrochloride Structure

38061-25-5

α-(3,4,5-Trimet...

~%

2-methyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-20-9

2-methyl-5-(3,4...

Methyl N-acetyl-3,5-dimethoxy-O-methyl-β-oxotyrosinate Structure

89205-26-5

Methyl N-acetyl...

~%

2-methyl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-20-9

2-methyl-5-(3,4...

α-(3,4,5-Trimethoxyphenyl)acyl amino acid methyl ester hydrochloride Structure

38061-25-5

α-(3,4,5-Trimet...

~%

2-propan-2-yl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-21-0

2-propan-2-yl-5...

methyl 2-isobutyramido-3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate Structure

89205-27-6

methyl 2-isobut...

~%

2-propan-2-yl-5-(3,4,5-trimethoxyphenyl)-1,3-oxazole-4-carboxamide Structure

89205-21-0

2-propan-2-yl-5...


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