UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2, 2′-dithiocinnamate derivatives and 2, 2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological ...
