Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action

L Florvall, I Fagervall, AL Ask…

Index: Florvall, Lennart; Fagervall, Ingrid; Ask, Anna-Lena; Ross, Svante B. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2250 - 2256

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Citation Number: 18

Abstract

Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MA0 within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MA0 in vitro. Some of the compounds inhibited the MA0 within the monoaminergic neurons at much lower doses than those required for inhibition of MA0 within other cells in vivo. ...