The synthesis of four deuterated sialic acids and their 1, 7-lactones has been performed in two ways, one based on sialic acid classical chemistry, and the other involving a direct exchange of the unlabeled acyl group of N-acetylneuraminic acid with a labeled one mediated by a perfluorinated amide. The final lactonization is promoted by benzyloxycarbonyl chloride.
![(2S,4S,5S,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydro xypropyl]tetrahydropyran-2-carboxylic acid Structure](https://image.chemsrc.com/caspic/382/19342-33-7.png)
