Carbohydrate Research

Synthesis, characterization, and conformation in solution of a novel d-glucurono-6, 1-lactam derivative

Y Takeda, T Akimoto, Y Kyogoku

Index: Takeda, Yasuko; Akimoto, Toshio; Kyogoku, Yoshimasa Carbohydrate Research, 1982 , vol. 106, p. 175 - 192

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Citation Number: 9

Abstract

Abstract Prolonged treatment of 2′-(sodium β-d-glucopyranosyluronate) isonicotinohydrazide with acetic anhydride in the presence of pyridine at room temperature for∼ 110 h gave 2, 3, 4-tri-O-acetyl-N-(diacetylamino)-β-d-glucopyranurono-1, 6-lactam (2), a novel d-glucorono-6, 1-lactam derivative. Its conformation in solution, examined by 1 H- and 13 Cn. mr and compared with the crystal structure, corresponds to a fairly rigid ring ...