e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

En route to tetra-t-butylethylene

A Krebs, B Kaletta, WU Nickel, W Rüger, L Tikwe

Index: Krebs, Adolf; Kaletta, Bernd; Nickel, Wolf-Ulrich; Rueger, Wolfgang; Tikwe, Liane Tetrahedron, 1986 , vol. 42, # 6 p. 1693 - 1702

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Citation Number: 28

Abstract

Triene 22 was synthesized and converted by two different routes to the tetraaldehyde 27, the first “non-bridged” derivative of 1. An X-ray analysis of 27 reveals that the C C bond is twisted by 28.6°. Attempts to prepare 1 from 27 failed, thus far. Addition of t-butyllithium to 13, subsequent reaction with ethylene oxide and further reactions led to the highly strained tri-t- butylethylethylene 33; according to force field calculations 33 has the largest ...

bis-cis-3,4-dihydroxy-2,2,5,5-tetramethylcyclopentanylidene Structure

bis-cis-3,4-dih...

~25%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

3-(3,4-dihydroxy-2,2,5,5-tetramethylcyclopentylidene)-2,2,4,4-tetramethylpentanedial Structure

3-(3,4-dihydrox...

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2,2,4,4-tetramethylcyclopentane-1,3-dione Structure

2,2,4,4-tetrame...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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2,2,5,5-tetramethylcyclopent-3-en-1-one Structure

2,2,5,5-tetrame...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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2,2,5,5-tetramethyl-3-hydroxycyclopentanone Structure

2,2,5,5-tetrame...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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2,2,4,4-tetramethyl-3-oxocyclopentylxanthogenate Structure

2,2,4,4-tetrame...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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4-diazo-3,3,5,5-tetramethylcyclopentene Structure

4-diazo-3,3,5,5...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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1,1,4,4,8,8,11,11-octamethyl-6-thia-12,13-diazadispiro(4.1.4.2)trideca-2,9,12-triene Structure

1,1,4,4,8,8,11,...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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1,1,4,4,8,8,11,11-octamethyl-6-thiadispiro(4.0.4.1)undeca-2,9-diene Structure

1,1,4,4,8,8,11,...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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2,2,2',2',5,5,5',5'-octamethyl-[1,1'-bi(cyclopentylidene)]-3'-ene-3,4-diol Structure

2,2,2',2',5,5,5...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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3,3,6,6,8,8-hexamethyl-7-(2',2',5',5'-tetramethylcyclopent-3-ene-1-ylidene)-2,4-dioxabicyclo(3.3.0)octane Structure

3,3,6,6,8,8-hex...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

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3,3,6,6,8,8-hexamethyl-7-(2',2',5',5'-tetramethyl-3,4-dihydroxycyclopentylidene)-2,4-dioxabicyclo(3.3.0)octane Structure

3,3,6,6,8,8-hex...

~%

2,2,5,5-tetramethyl-3,4-bis(2-methyl-1-oxopropan-2-yl)hex-3-enedial Structure

2,2,5,5-tetrame...

Learn More

2,2,5,5-tetramethylcyclopent-3-en-1-one Structure

2,2,5,5-tetrame...

~88%

(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

Learn More

2,2,4,4-tetramethylcyclopentane-1,3-dione Structure

2,2,4,4-tetrame...

~%

(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

Learn More

2,2,5,5-tetramethyl-3-hydroxycyclopentanone Structure

2,2,5,5-tetrame...

~%

(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

Learn More

2,2,4,4-tetramethyl-3-oxocyclopentylxanthogenate Structure

2,2,4,4-tetrame...

~%

(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

Learn More

(2,2,5,5-tetramethylcyclopent-3-en-1-ylidene)hydrazine Structure

(2,2,5,5-tetram...

~69%

2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

Learn More

2,2,4,4-tetramethylcyclopentane-1,3-dione Structure

2,2,4,4-tetrame...

~%

2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

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2,2,5,5-tetramethylcyclopent-3-en-1-one Structure

2,2,5,5-tetrame...

~%

2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

Learn More

2,2,5,5-tetramethyl-3-hydroxycyclopentanone Structure

2,2,5,5-tetrame...

~%

2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

Learn More

2,2,4,4-tetramethyl-3-oxocyclopentylxanthogenate Structure

2,2,4,4-tetrame...

~%

2,2,5,5-tetramethylcyclopent-3-ene-1-thione Structure

2,2,5,5-tetrame...

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Sterisch gehinderte Alkene, VII Röntgenstrukturanalyse und R...

[Krebs, Adolf; Nickel, Wolf-Ulrich; Tikwe, Liane; Kopf, Juergen Tetrahedron Letters, 1985 , vol. 26, # 13 p. 1639 - 1642]

Preparation and reactions of tetrakis (2-formyl-2-propyl) et...

[Cullen, Edward R.; Guziec, Frank S. Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1212 - 1216]