On the synthesis of 3 (5)??carbomethoxy??4??hetarylpyrazoles

C Cativiela, D Villegas, MD Diaz…

Index: Cativiela, Carlos; Villegas, Maria D. Diaz de; Mayoral, Jose A.; Avenoza, Alberto; Roy, Miguel A. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 851 - 855

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Citation Number: 24

Abstract

Abstract 3 (5)-Carbomethoxy-4-hetarylpyrazoles 3 can be obtained by the aromatization of the corresponding cis-3-benzamido-3-carbomethoxy-4-hetaryl-Δ 1-pyrazolines 2 obtained by 1, 3-dipolar cycloaddition of diazo-methane with methyl Z-2-benzamido-3- hetarylpropenoates 1. An explanation, based on FMO theory, for the different reactivity of the dipolarophiles with diazomethane is given.