Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine. beta.-hydroxylase

…, WE DeWolf Jr, JS Frazee, RW Erickson…

Index: Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Frazee, James S.; Erickson, Robert W.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 887 - 889

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Citation Number: 33

Abstract

Dopamine 0-hydroxylase (DBH; EC 1.14. 17.1), a copper-containing mixed-function oxidase, catalyzes the penultimate step in the catecholamine biosynthetic pathway, the benzylic oxidation of dopamine (DA) to norepinephrine (NE). 2 This enzymatic transformation affords a particularly attractive point for biochemical modulation of catecholamine levels in vivo. A selective DBH inhibitor would be expected to lower NE ...