In the search for novel inhibitors of the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism, we have had occasion to look at several series of hydroxamic acids, two examples of which are described within. The 5-LO pathway leads to several compounds with extremely potent biological activities: leukotriene B4 (LTB4) has been shown1 to be a potent chemotactic agent in vivo, while the peptido leukotrienes LTC4 and LTD4 are ...
