An approach to the tricyclic core of madangamines based upon a biogenetic scheme

…, MT Martin, A Chiaroni, M Bénéchie, C Marazano

Index: Han, Min Tong; Martin, Marie-Therese; Chiaroni, Angele; Benechie, Michel; Marazano, Christian Organic Letters, 2005 , vol. 7, # 12 p. 2437 - 2440

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Citation Number: 17

Abstract

A short synthesis of intermediates possessing the tricyclic core of natural madangamines, bioactive alkaloids found in marine sponges, is described. The key reaction entails the condensation of the sodium salt of diethylacetonedicarboxylate with a dihydropyridinium salt derivative. This new approach is modeled on a biogenetic proposal linking madangamines to ircinals, related alkaloids occurring in sponges of the same order.

N-Heteroarylmethyl-5-hydroxy-1, 2, 5, 6-tetrahydropyridine-3...

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Convenient Formal Synthesis of (±)??Paroxetine

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