Synthesis of homaline and epi-homaline

L Crombie, RCF Jones, AR Mat-Zin…

Index: Crombie, Leslie; Jones, Raymond C. F.; Mat-Zin, Ab. Rasid; Osborne, Steven Journal of the Chemical Society, Chemical Communications, 1983 , # 17 p. 960 - 961

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Abstract

5-Methyl-4-phenyl-1, 5-diazacycla-octan-2-one has been prepared by cyclisation of an acyclic precursor or by transamidation from 4-phenylazetidin-2-one, and converted into natural (–)-homaline and-homaline: the approach is applicable to the synthesis of unsymmetrical alkaloids.