Tetrahedron letters

Convenient synthesis of 2-thionaphthylmethyl isocyanide: A useful reagent for methyl isocyanide transfer

S Ranganathan, WP Singh

Index: Ranganathan, S.; Singh, W. P. Tetrahedron Letters, 1988 , vol. 29, # 12 p. 1435 - 1436

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Citation Number: 2

Abstract

ABSTRACT: The crystalline 2-thionaphthylmethyl isocyanide (L), prepared from the novel N- (formamidomethyl)-N-benzyl morpholinium iodide (21, via transfer of elements of CH2h+ CH0, is totally devoid of pervasive odour. The cycle-addition of the conjugate base of (I) to mtrrles followed by desulfurization, under very mild conditions, provides an attractive route to i&dazoles.