Tetrahedron Letters

A clean, palladium-catalyzed oxidative esterification of aldehydes using benzyl chloride

GA Heropoulos, C Villalonga-Barber

Index: Heropoulos, Georgios A.; Villalonga-Barber, Carolina Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5319 - 5322

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Citation Number: 13

Abstract

A highly efficient, mild, simple and clean procedure is presented for the one-pot oxidation of aromatic and aliphatic aldehydes to their corresponding ethyl esters using benzyl chloride as the oxidant under palladium-catalyzed conditions. The reaction is complete in just 30min under microwave irradiation and inert conditions are not required to obtain good to excellent yields (65–93%) of isolated products.