Synthesis of PHI (peptide histidine isoleucine) and related peptides and immunochemical confirmation of amino acid residue in position 24 of PHI with use of the …

K Nokihara, C Yanaihara, K Iguchi…

Index: Nokihara, K.; Yanaihara, C.; Iguchi, K.; Fukata, S.; Tanaka, M.; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 25 p. 7909 - 7916

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Citation Number: 16

Abstract

Abstract: An immunochemical approach, using synthetic peptides, was employed to establish the nature of residue 24 in the amino acid sequence of PHI (peptide histidine isoleucine). PHI (20-27) and [Gln24]-PHI (20-27) were synthesized by conventional solution methods and were used as haptenic immunogens for production of antisera. An antiserum raised against [Glr~~~]-PHI (20-27), R8304, was shown to recognize specifically the ...