Tetrahedron letters

Base-labile tert-butoxycarbonyl (Boc) group on phenols

K Nakamura, T Nakajima, H Kayahara, E Nomura…

Index: Nakamura, Kozo; Nakajima, Takero; Kayahara, Hiroshi; Nomura, Eisaku; Taniguchi, Hisaji Tetrahedron Letters, 2004 , vol. 45, # 3 p. 495 - 499

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Citation Number: 19

Abstract

Phenols are deprotected with weak bases from their tert-butoxycarbonyl (Boc) derivatives. Boc deprotection with bases can avoid side reactions during the deprotection with acids. We note the lability of the Boc to bases and are able to utilize it as a new cleavage condition for synthetic studies.