Syntheses and evaluation as antifolates of MTX analogs derived from 2,. omega.-diaminoalkanoic acids

…, GS McCaleb, JA Montgomery, FA Schmid…

Index: Piper, J. R.; McCaleb, G. S.; Montgomery, J. A.; Schmid, F. A.; Sirotnak, F. M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1016 - 1025

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Citation Number: 23

Abstract

BOC=(CH313COC0 rivative for use as a reporter ligand for DHFR. 15 Kumar et al. converted the ornithine and lysine analogues to their N"-dansyl derivatives, which also have proved useful as DHFR probes because of their fluorescent properties and potent inhibition of DHFR. lB-la Chemistry. In this report we describe alternative syntheses of the ornithine analogue 27c and the two lower homologues 27a, b. From 27a-c or appropriate ...