Indanylacetic acids as PPAR-δ activator insulin sensitizers

P Wickens, C Zhang, X Ma, Q Zhao, J Amatruda…

Index: Wickens, Philip; Zhang, Chengzhi; Ma, Xin; Zhao, Qian; Amatruda, John; Bullock, William; Burns, Michael; Cantin, Louis-David; Chuang, Chih-Yuan; Claus, Thomas; Dai, Miao; Dela Cruz, Fernando; Dickson, David; Ehrgott, Frederick J.; Fan, Dongping; Heald, Sarah; Hentemann, Martin; Iwuagwu, Christiana I.; Johnson, Jeffrey S.; Kumarasinghe, Ellalahewage; Ladner, David; Lavoie, Rico; Liang, Sidney; Livingston, James N.; Lowe, Derek; Magnuson, Steve; Mannelly, Gretchen; Mugge, Ingo; Ogutu, Herbert; Pleasic-Williams, Susan; Schoenleber, Robert W.; Shapiro, Jeff; Shelekhin, Tatiana; Sweet, Laurel; Town, Christopher; Tsutsumi, Manami Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4369 - 4373

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Citation Number: 14

Abstract

A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-α and PPAR-δ ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-δ over PPAR-α. ... A novel series of indane acetic acid molecules are insulin sensitizers and have selectivity for PPAR-δ agonist activity over PPAR-α. ... The PPAR-γ/-δ combination remains relatively unexplored, however. 11 and 12 A recent ...