Crystal structure of chiral γPNA with complementary DNA strand: Insights into the stability and specificity of recognition and conformational preorganization

…, S Rapireddy, MJ Crawford, RR Gil…

Index: Dragulescu-Andrasi, Anca; Rapireddy, Srinivas; Frezza, Brian M.; Gayathri, Chakicherla; Gil, Roberto R.; Ly, Danith H. Journal of the American Chemical Society, 2006 , vol. 128, # 31 p. 10258 - 10267

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Citation Number: 50

Abstract

We have determined the structure of a PNA− DNA duplex to 1.7 Å resolution by multiple- wavelength anomalous diffraction phasing method on a zinc derivative. This structure represents the first high-resolution 3D view of a hybrid duplex containing a contiguous ...