Azabenzocycloheptenones. Part 20. Synthesis and utilisation of 4-amino-1, 2, 3, 4-tetrahydro-1 (1 H)-benzazepines

KI Booker-Milburn, IR Dunkin, FC Kelly…

Index: Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273

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Citation Number: 22

Abstract

1, 2, 3, 4-Tetrahydro-6-and-7-methoxy-4-oxo-1-(p-tolylsulfonyl) quinolines 3 (Rá= átosyl, Xá= á6-and 7-OMe) and 1-ethoxycarbonylmethyl-1, 2, 3, 4-tetrahydro-7-methoxy-4- oxoquinoline 3 (Rá= áCH2CO2Et, Xá= á7-OMe) have been ring-expanded in two steps to 2, 3, 4, 5-tetrahydro-7-and-8-methoxy-4-oxo-1-(p-tolylsulfonyl)-1H-1-benzazepines 2 (Rá= átosyl, Xá= á7-and-8-OMe) and 1-ethoxycarbonylmethyl-2, 3, 4, 5-tetrahydro-8-methoxy-4 ...