Deracemization and the first CD spectrum of a 3 10-helical peptide made of achiral α-amino-isobutyric acid residues in a chiral membrane mimetic environment

F Ceccacci, G Mancini, P Rossi, P Scrimin…

Index: Ceccacci, Francesca; Mancini, Giovanna; Rossi, Paola; Scrimin, Paolo; Sorrenti, Alessandro; Tecilla, Paolo Chemical Communications, 2013 , vol. 49, # 86 p. 10133 - 10135

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Citation Number: 4

Abstract

Interaction of the racemic helical homo-octapeptide made by the achiral Cα-methyl alanine (Aib) amino acid with a chiral enantiopure micellar aggregate made of N-dodecylproline led to the deracemization of the helical Aib sequence thus allowing us to obtain for the first time the CD signature in water of a 310 helix devoid of the contribution of any chiral amino acid.