The electrophilic halogenation reaction of olefins coupled with cascade carbocyclization is an iconic biomimetic process for the construction of complex molecules.[1] In 2007, Ishihara and co-workers reported the first example of enantioselective iodocarbocyclization of polyenes with N-iodosuccinimide, a reaction promoted by stoichiometric quantities of a chiral phosphoramidite nucleophile.[2] This system was less effective for bromo-and ...
