Lipase-catalyzed aza-Michael reaction on acrylate derivatives

P Steunenberg, M Sijm, H Zuilhof…

Index: Steunenberg, Peter; Sijm, Maarten; Zuilhof, Han; Sanders, Johan P. M.; Scott, Elinor L.; Franssen, Maurice C. R. Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3802 - 3813

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Citation Number: 14

Abstract

A methodology has been developed for an efficient and selective lipase-catalyzed aza- Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was ...