Synthesis and biological activity of 3-aryl-1.3-bis (dialkylaminomethyl)-2-oxoindolines

VV Bolotov, SM Drogovoz, LV Yakovleva

Index: Bolotov, V. V.; Drogovoz, S. M.; Yakovleva, L. V. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 630 - 632 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1060 - 1063

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Abstract

We have already shown [i, 2] that 3, 3-diaryl-3-oxoindolines undergo aminomethylation at position 1 to form l-aminomethyl-3-diaryl-2-oxoindolines with antiinflammatory activity. In the literature a case is described [3, 4] of aminomethylation at position 3 of 1, 3-disubstituted