Oxidative CH amination of N-trichloroethoxysulfonyl-protected ureas and guanidines is demonstrated to proceed in high yield for tertiary and benzylic-derived substrates. The success of these reactions is predicated on the choice of the electron-withdrawn 2, 2, 2- trichloroethoxysulfonyl (Tces) protecting group, the commercial catalyst Rh2 (esp) 2 (1-2 mol%), and toluene as solvent. The frequency with which the heterocyclic imidazolidin-2- ...
