Alkyl Radical Generation in Water under Ambient Conditions—A New Look at the Guareschi Reaction of 1897

…, M Piacenti, JM Brown, AS Dorofeev…

Index: Nguyen, Bao; Chernous, Katya; Endlar, Daniel; Odell, Barbara; Piacenti, Michela; Brown, John M.; Dorofeev, Alexander S.; Burasov, Alexander V. Angewandte Chemie - International Edition, 2007 , vol. 46, # 40 p. 7655 - 7658

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Citation Number: 14

Abstract

In a series of papers initially published between 1897 and 1901, I. Guareschi (Turin) and his colleagues reported the synthesis of 4, 4'-dialkyl-3, 5-dicyanoglutarimides by the condensation of ketones other than acetone with ethyl cyanoacetate in ethanolic ammonia.[1, 2] The reaction has frequently been used subsequently as a route to functional quaternary centers,[3] and because glutarimides have shown potential as drugs.[4] In ...