Ruthenium??catalyzed synthesis of quinolines via reductive heteroannulation of nitroarenes with 3??amino??1??propanols

…, TK Kim, TJ Kim, SC Shim, NS Yoon

Index: Cho, Chan Sik; Kyung Kim, Tae; Kim, Tae-Jeong; Shim, Sang Chul; Yoon, Nam Sik Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 2 p. 291 - 294

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Citation Number: 7

Abstract

Abstract Nitroarenes are reductively cyclized with 3-amino-1-propanols in dioxane/H 2 O in the presence of a ruthenium catalyst and tin (II) chloride dihydrate together with isopropanol to afford the corresponding quinolines. A reaction pathway involving initial reduction of nitroarenes to anilines, propanol group transfer from 3-amino-1-propanols to anilines, N- alkylation of anilines by 3-anilino-1-propanols and heteroannulation of 1, 3- ...