Evaluation of novel aryloxyalkyl derivatives of imidazole and 1, 2, 4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties

…, R Acquaviva, I Barbagallo, D Tibullo, V Sorrenti

Index: Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Siracusa, Maria A.; Di Giacomo, Claudia; Acquaviva, Rosaria; Barbagallo, Ignazio; Tibullo, Daniele; Sorrenti, Valeria Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5145 - 5153

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Citation Number: 12

Abstract

Abstract A novel series of aryloxyalkyl derivatives of imidazole and 1, 2, 4-triazole, 17–31, was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). Some of these compounds were found to be good inhibitors of HO-1, in particular those carrying an imidazole moiety as azolyl group and a 3-bromo or 4- iodophenyl as aryl moiety. The most potent compounds 6 and 30 were selected and ...