Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine …

…, F Palazzo, JL Wilsbacher, Q Zhang, LA Tucker…

Index: Hubbard, Robert D.; Bamaung, Nwe Y.; Fidanze, Steve D.; Erickson, Scott A.; Palazzo, Fabio; Wilsbacher, Julie L.; Zhang, Qian; Tucker, Lora A.; Hu, Xiaoming; Kovar, Peter; Osterling, Donald J.; Johnson, Eric F.; Bouska, Jennifer; Wang, Jieyi; Davidsen, Steven K.; Bell, Randy L.; Sheppard, George S. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1718 - 1721

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Citation Number: 22

Abstract

Emerging clinical and pre-clinical data indicate that both insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor (EGF) family of receptor tyrosine kinases (RTKs) exhibit significant cross-talk in human cancers. Therefore, a small molecule that successfully inhibits the signaling of both classes of oncogenic kinases might provide an attractive agent for chemotherapeutic use. Herein, we disclose the structure activity ...