Discovery of 8-hydroxyadenines as a novel type of interferon inducer

K Hirota, K Kazaoka, I Niimoto…

Index: Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi Heterocycles, 1985 , vol. 23, # 1 p. 205

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Citation Number: 75

Abstract

9-Benzyl-8-hydroxyadenine (6) was found to possess interferon-inducing activity in vitro as a lead compound. Although replacement of the 9-benzyl group of 6 did not improve the activity, the introduction of a substituent such as alkyl, alkylthio, alkylamino, and alkoxy