Synthesis

Synthesis of 4-amino-3-pyridinyl and 4-amino-5-pyrimidinyl aryl ketones and related compounds via an ortho-lithiation reaction

R Radinov, M Haimova, E Simova

Index: Radinov, Rumen; Haimova, Marietta; Simova, Ekaterina Synthesis, 1986 , # 11 p. 886 - 891

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Citation Number: 33

Abstract

Scheme C l'apei'.\'337 achieved with ammonia solutions at lL 'l1" tPL" l 'illLll” L '.\ l\ ClU 'i\ 1 () U “(. f; compound Ila could be obtained in ot ')“rii _vicl< l., however. by using the standard procedure", ic by heating compound 8a with aqueous Z5"/11 animonia at 135 I95 '('in it pressure vessel. The combined elect ron-witlidrawiiig eltects of the two ring l\ l-atoms facilitate the nucleophilie substitution of the 4~ Cl atom in the 4.6-tlichloropyrimidine (9a) ...