Synthesis, in vitro [3H] prazosin displacement, and in vivo activity of 3-aryl-4, 5, 6, 7-tetrahydropyrazolo [4, 3-c] pyridines, a new class of antihypertensive agents

G Winters, A Sala, D Barone…

Index: Winters, Giorgio; Sala, Alberto; Barone, Domenico; Baldoli, Emiliana Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 934 - 940

Full Text: HTML

Citation Number: 21

Abstract

The a-adrenoceptor antagonists prazosin, corynanthine, and WB 4101 lower blood pressure mainly by blocking postsynaptic a,-adrenoceptors on the vascular effector Prazosin, which may also have central a-blocking activity; is the only one used in antihypertensive therapy, but its use is restricted by a serious side effect, namely," the first-dose phenomenonn, a severe initial hypotension associated with syncope."'During a program of synthesis of new ...

 Related Synthetic Route
1-[3-(3-chloro-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone Structure

87628-32-8

1-[3-(3-chloro-...

~82%

3-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-44-2

3-(3-chlorophen...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

3-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-44-2

3-(3-chlorophen...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

3-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-44-2

3-(3-chlorophen...

1-acetyl-3-(3-chlorobenzoyl)piperidin-4-one Structure

148363-35-3

1-acetyl-3-(3-c...

~%

3-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-44-2

3-(3-chlorophen...

4-(5-acetyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)benzonitrile Structure

87628-34-0

4-(5-acetyl-4,5...

~71%

4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)benzonitrile Structure

87628-46-4

4-(4,5,6,7-tetr...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)benzonitrile Structure

87628-46-4

4-(4,5,6,7-tetr...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)benzonitrile Structure

87628-46-4

4-(4,5,6,7-tetr...

1-(3-(3,4-dimethoxyphenyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one Structure

87628-38-4

1-(3-(3,4-dimet...

~91%

3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-48-6

3-(3,4-dimethox...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-48-6

3-(3,4-dimethox...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87628-48-6

3-(3,4-dimethox...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

1-acetyl-3-(4-fluorobenzoyl)piperidin-4-one Structure

87642-26-0

1-acetyl-3-(4-f...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

1-acetyl-3-(4-fluorobenzoyl)piperidin-4-one Structure

87642-26-0

1-acetyl-3-(4-f...

1-[3-(4-methoxy-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone Structure

87628-29-3

1-[3-(4-methoxy...

~82%

3-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine Structure

87628-42-0

3-(4-methoxyphe...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

3-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine Structure

87628-42-0

3-(4-methoxyphe...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

3-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine Structure

87628-42-0

3-(4-methoxyphe...

N/A Structure

148363-39-7

N/A

~%

3-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine Structure

87628-42-0

3-(4-methoxyphe...

1-(3-(p-tolyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)-ethanone Structure

87628-30-6

1-(3-(p-tolyl)-...

~62%

3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87642-32-8

3-(4-Methylphen...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87642-32-8

3-(4-Methylphen...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87642-32-8

3-(4-Methylphen...

1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Structure

87628-26-0

1-(3-phenyl-1,4...

~77%

3-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE Structure

87642-29-3

3-PHENYL-4,5,6,...

N/A Structure

148363-38-6

N/A

~%

3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine Structure

87642-32-8

3-(4-Methylphen...

N/A Structure

144507-37-9

N/A

~%

1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Structure

87628-26-0

1-(3-phenyl-1,4...

1-Acetyl-4-piperidinone Structure

32161-06-1

1-Acetyl-4-pipe...

~%

1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Structure

87628-26-0

1-(3-phenyl-1,4...

1-(4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl)ethanone Structure

55459-60-4

1-(4-morpholin-...

~%

1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Structure

87628-26-0

1-(3-phenyl-1,4...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved