Hydrogen??Bond??Promoted Palladium Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1, 3??Disubstituted Allyl Acetates Using Chiral Bis (sulfoxide) …

L Du, P Cao, J Xing, Y Lou, L Jiang…

Index: Du, Le; Cao, Peng; Xing, Junwei; Lou, Yazhou; Jiang, Liyin; Li, Liangchun; Liao, Jian Angewandte Chemie - International Edition, 2013 , vol. 52, # 15 p. 4207 - 4211 Angew. Chem., 2013 , vol. 125, # 15 p. 4301 - 4305,5

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Citation Number: 54

Abstract

The palladium-catalyzed asymmetric allylic alkylation (AAA, Tsuji–Trost reaction) is a powerful strategy for construction of carbon–carbon (CÀC) and carbon–heteroatom (CÀX) bonds.[1] Various ligands, such as monodentate phosphines, bidentate N, N-, P, N-, P, P- ligands, etc., have been used in this reaction, especially for symmetric 1, 3-disubstituted allylic substrates.[1g, 2] To date, asymmetric alkylation (CÀC bond formation) of racemic, ...