Synthetic studies on the relationship between anti-HIV activities and micelle forming abilities of various alkylated glycyrrhetinate diglycoside sodium sulfates and …

…, M Ochiai, A Hosono, H Hoshino, U Haraguchi…

Index: Saito; Furumoto; Ochiai; Hosono; Hoshino; Haraguchi; Ikeda; Shimada European Journal of Medicinal Chemistry, 1996 , vol. 31, # 5 p. 365 - 381

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Citation Number: 25

Abstract

Sodium sulfates 11–14, 29–32, 35 and 37 of various alkyl glycyrrhizin and related compounds were synthesized. In vitro anti-HIV activities of the sulfates were compared to the activities of glycyrrhizin 1 in the inhibition of replications of HTLV-III and GUN-4. The activities of the sulfates were increased 11.1, 15.2, 9.1 and 5.0 times for 11-14, 100.0, 125.5, 83.3 and 11.6 times for 29-32, and 11.6 and 50.0 times for 35 and 37. From the ...