Molecules

Cooperative Al (Salen)-Pyridinium Catalysts for the Asymmetric Synthesis of trans-Configured β-Lactones by [2+ 2]-Cyclocondensation of Acylbromides and …

P Meier, F Broghammer, K Latendorf, G Rauhut…

Index: Meier, Patrick; Broghammer, Florian; Latendorf, Katja; Rauhut, Guntram; Peters, Rene Molecules, 2012 , vol. 17, # 6 p. 7121 - 7150

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Citation Number: 15

Abstract

Abstract The trans-selective catalytic asymmetric formation of β-lactones constitutes an attractive surrogate for anti-aldol additions. Recently, we have reported the first catalyst which is capable of forming trans-β-lactones with high enantioselectivity from aliphatic (and aromatic) aldehyde substrates by cyclocondensation with acyl bromides. In that previous study the concepts of Lewis acid and organic aprotic ion pair catalysis were combined in a ...