Silica-Supported 2, 4, 6-Trichloro-1, 3, 5-triazine as an Efficient Reagent for Direct Conversion of Carboxylic Acids to Amides Under Solvent-Free Conditions

A Khalafi-Nezhad, A Zare, A Parhami…

Index: Khalafi-Nezhad, Ali; Zare, Abdolkarim; Parhami, Abolfath; Rad, Mohammad Navid Soltani; Nejabat, Gholam Reza Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 3 p. 657 - 666

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Citation Number: 26

Abstract

A very simple and efficient solvent-free method for the direct conversion of carboxylic acids to primary, secondary, tertiary alkyl, and aromatic amides in the presence of the corresponding ammonium salts, silica-supported 2, 4, 6-trichloro-1, 3, 5-triazine, and triethylamine is described. The reactions proceed rapidly at room temperature, and the products are obtained in moderate to excellent yields.