Journal of Heterocyclic Chemistry

Facile synthesis of N??substituted??4??cyano??4??phenylpiperidines via phase??transfer catalysis

D Thompson, PC Reeves

Index: Thompson, Doug; Reeves, Perry C. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 771 - 772

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Citation Number: 12

Abstract

Abstract Phenylacetonitrile can be condensed with N-substituted-bis (2-chloroethyl) amines in aqueous sodium hydroxide solution to produce N-substituted-4-cyano-4- phenylpiperidines. Hexadecyltributylphosphonium bromide is an effective catalyst for this phase-transfer reaction.