Synthetic communications

A simple and efficient method for the preparation of heterocyclic N-oxide

P Zhong, S Guo, C Song

Index: Zhong, Ping; Guo, Sheng-Rong; Song, Cai-Sheng Synthetic Communications, 2004 , vol. 34, # 2 p. 247 - 253

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Citation Number: 11

Abstract

Abstract Pyridine, 2-methylpyridine, 3-methylpyridine, 4-methylpyridine, 2, 4- dimethylpyridine, 2, 6-dimethylpyridine, quinoline, isoquinoline and 2-chloropyridine are readily oxidized to their N-oxides with a solution of trichloroisocyanuric acid, acetic acid, sodium acetate and water in acetonitrile and methylene dichloride in 78%–90% yields.