e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Fused Polycyclic Nitrogen-Containing Heterocycles: VIII. Friedel–Crafts Intramolecular Cyclization of 5-Phenylthiazole-4-carboxylic Acids—A New Route to Indeno [2, …
Abstract Friedel–Crafts intramolecular cyclization in the presence of polyphosphoric acid of 2-substituted 5-phenylthiazole-4-carboxylic acids, which are obtained by alkaline hydrolysis of the corresponding esters, leads to indeno [2, 1-d] thiazoles. According to the X-ray diffraction data, packing of their molecules in crystal is determined mainly by intermolecular π–π contacts, regardless of the substituent nature.
