Various (E)-β-(pyrimidin-5-yl) acrylamides (4 and 5) were synthesized as sparsomycin analogs, and the relationship between chemical structure and antitumor activity was examined. Synthesis involved condensation of appropriate acids (3) and methyl methioninate (L and D isomers) by the mixed anhydride method using isobutyl chlorocarbonate. The antitumor activity was studied by [methyl-3 H] thymidine ...
