Tetrahedron

Reactions of trifluoromethylpyridines with alkyllithium reagents. Directing effects of the trifluoromethyl groups

J Porwisiak, W Dmowski

Index: Porwisiak, Jacek; Dmowski, Wojciech Tetrahedron, 1994 , vol. 50, # 42 p. 12259 - 12266

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Citation Number: 19

Abstract

Reactions of eight trifluoromethyl substituted pyridines with alkyllithium reagents were examined. 3-Trifluoromethylpyridine, 3, 4-, and 3, 5-bis (trifluoromethyl) pyridines undergo regioselective lithiation at the 2-position thus providing an easy access to 2-functionalised trifluoromethylpyridines. The reactions of 2-trifluoromethylpyridine, 2, 4-, 2, 6-bis (trifluoromethyl)-pyridines and 2, 4, 6-tris (trifluoromethyl) pyridine result exclusively by ...