Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, …

Z Huang, CA Velázquez, KRA Abdellatif…

Index: Meissner, Dana; Schareina, Thomas; Grassert, Ingrid; Oehme, Guenther; Holzhueter, Gerd Advanced Synthesis and Catalysis, 1996 , vol. 338, # 7 p. 614 - 619

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Citation Number: 36

Abstract

... are devoid of adverse ulcerogenic and/or cardiovascular side effects, we now describe the synthesis of a ... or ibuprofen with oxalyl chloride in dry CH 2 Cl 2 and a catalytic amount of ... 2 NHOH), thereby providing release of HNO at physiological pH, attempts to synthesize the −CH ...