The Development of a New Manufacturing Route to the Novel Anticonvulsant, SB-406725A

…, AJ Burton, LD Humphreys, G Kelly…

Index: Oganesyan, Asmik; Cruz, Iris A.; Amador, Roberto B.; Sorto, Nohemy A.; Lozano, Jose; Godinez, Carlos E.; Anguiano, Jaime; Pace, Heather; Sabih, Ghiwa; Gutierrez, Carlos G. Organic Letters, 2007 , vol. 9, # 24 p. 4967 - 4970

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Citation Number: 5

Abstract

... Telephone: 01438 768179. Fax: 01438 764242. E-mail: matthew.d.walker@gsk.com. ... Our initial attempts to synthesise 5,8-dichloroisoquinoline 11 were carried out on up to 20 g scale via the Pommerantz−Fritsch reaction. ... entry, conditions a, product b (%), 4-NO 2 isomer (%). ...