Mechanistic studies on prolyl-4-hydroxylase: the vitamin C requiring uncoupled oxidation

…, H Moon, A Pirskanen, J Myllyharju, KI Kivirikko…

Index: Wu, Min; Moon, Hong-sik; Pirskanen, Asta; Myllyharju, Johanna; Kivirikko, Kari I.; Begley, Tadhg P. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1511 - 1514

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Citation Number: 14

Abstract

A deuteriated substrate for the human type I prolyl-4-hydroxylase was synthesized and its V/K deuterium isotope effect was determined to be 3.4±0.2. This isotope effect was attributed to the uncoupled oxidation. A dehydroproline containing tetrapeptide was also found to stimulate the uncoupled oxidation.

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