First enantioselective total synthesis of (+)-cortisone

H Nemoto, N Matsuhashi, M Imaizumi…

Index: Nemoto, Hideo; Matsuhashi, Norikazu; Imaizumi, Mari; Nagai, Mitsuo; Fukumoto, Keiichiro Journal of Organic Chemistry, 1990 ,  vol. 55,  # 21  p. 5625 - 5631

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Citation Number: 39

Abstract

Corticosteroids that have an oxygen functionality at C-11 are important regulatory hormones. 2 Because of this physiological and also clinical importance, much effort has been devoted to solving the problems presented by this class of steroid^,^ especially developing efficient methods for introducing a hydr~ xyacetyl~ and an oxygen substituent5 at'2-17 and C-11 positions, respectively; such functionalities are important for steroidal physiological activity ...