5-Ethynyl-l-~-~-arabinofuranosylcyt~~ ine (EAC) was prepared from 1-(2, 3, 5-tri-0-acetyl-~- D-arabinofuranosy~) c~ os~ ne by iodination followed by coupling with (trimethylsily1) acetylene and deblocking. At 50 yM, EAC was found to inhibit the in vitro replication of herpes simplex virus type 1 and type 2 by> 99%. EAC also showed activity against a strain of HSV-1 resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine which has an alteration of the ...
