Synthesis and study of certain new disulfide derivatives of oxythiamine

TI Zimatkina, NA Kravchenya, BI Gorenshtein…

Index: Zimatkina, T. I.; Kravchenya, N. A.; Gorenshtein, B. I.; Ostrovskii, Yu. M. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 848 - 851 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1353 - 1356

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Abstract

T. he use of antivitamins as medicinal preparations is one of the modern trends in chemotherapy. But these compounds are usually used in experimental practice as specific agents for the inhibition of different vitamin-dependent reactions [i]. The attention of many authors is at present drawn to thiamine antimetabolites, which are artificially obtained derivatives of vitamin BI. To produce new effective thiamine antivitamins, taking into ...