The Journal of organic chemistry

Total Synthesis of Chlorocyclinone A, a PPAR-γ Antagonist

R Karmakar, D Mal

Index: Liau, Brian B.; Milgram, Benjamin C.; Shair, Matthew D. Journal of the American Chemical Society, 2012 ,  vol. 134,  # 40  p. 16765 - 16772

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Citation Number: 9

Abstract

... figure Scheme 6. Synthesis of Tetracyclic Chlorocyclinone 29 a. a Reagents and conditions: (a) Hg(OAc) 2 , NaOAc, AcOH, reflux, 2 h, 82%; (b) Tf 2 O, 2,6-lutidine, CH 2 Cl 2 , 0 °C–rt, N 2 atm, 18 h, 70%; (c) MeI, K 2 CO 3 , acetone, 0 °C–rt, 96%; (d) CO, MeOH, Et 3 N, dppf ...